[McMurdo]

Very large electrolytics are routinely used in 3-phase inverters to get a 580V dc bus for the transistor bridges. Normally, they use series-connected pairs of 400V rated caps, they always have so-called 'voltage-equalizing' resistors across them, sometimes as large as 27W or so on caps of 4700uF 400V or more each. I've not seen many large-capacity electrolytics used on their own (or readily available) at this sort of voltage.

I suppose modern film capacitors at 0.1uF or so have very little leakage at all.